Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1306171 | 1.00 | SIGMAR1 (0.41) | SIGMAR1HPGDRAB9AHTTSLC6A5 | |
| SCHEMBL1305925 | 0.96 | HPGD (0.42) | HPGDRAB9AHTTSLC6A5MAPT | |
| SCHEMBL1305928 | 0.96 | HPGD (0.42) | HPGDRAB9AHTTSLC6A5MAPT | |
| SCHEMBL1305319 | 0.92 | HPGD (0.44) | SIGMAR1HPGDRAB9AHTTSLC6A5 | |
| SCHEMBL1305316 | 0.92 | HPGD (0.44) | SIGMAR1HPGDRAB9AHTTSLC6A5 | |
| SCHEMBL29488468 | 0.91 | HDAC1 (0.45) | SIGMAR1HPGDRAB9AHTTSLC6A5 | |
| SCHEMBL1305734 | 0.91 | HDAC1 (0.45) | SIGMAR1HPGDRAB9AHTTSLC6A5 | |
| SCHEMBL1305731 | 0.91 | HDAC1 (0.45) | SIGMAR1HPGDRAB9AHTTSLC6A5 | |
| SCHEMBL1306649 | 0.88 | HPGD (0.46) | HPGDRAB9AHTTSLC6A5MAPT | |
| SCHEMBL1306644 | 0.88 | HPGD (0.46) | HPGDRAB9AHTTSLC6A5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |