Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1305731 | 1.00 | HDAC1 (0.45) | HDAC1HPGDRAB9AHTTHDAC8 | |
| SCHEMBL1305734 | 1.00 | HDAC1 (0.45) | HDAC1HPGDRAB9AHTTHDAC8 | |
| SCHEMBL1305316 | 0.92 | HPGD (0.44) | HPGDRAB9AHTTSIGMAR1SLC6A5 | |
| SCHEMBL1305319 | 0.92 | HPGD (0.44) | HPGDRAB9AHTTSIGMAR1SLC6A5 | |
| SCHEMBL1306172 | 0.91 | SIGMAR1 (0.41) | HPGDRAB9AHTTSIGMAR1SLC6A5 | |
| SCHEMBL1306171 | 0.91 | SIGMAR1 (0.41) | HPGDRAB9AHTTSIGMAR1SLC6A5 | |
| SCHEMBL1306649 | 0.88 | HPGD (0.46) | HPGDRAB9AHTTSLC6A5TP53 | |
| SCHEMBL1306644 | 0.88 | HPGD (0.46) | HPGDRAB9AHTTSLC6A5TP53 | |
| SCHEMBL1307239 | 0.88 | SLC6A5 (0.38) | HDAC1HPGDRAB9AHTTSIGMAR1 | |
| SCHEMBL1307246 | 0.88 | SLC6A5 (0.38) | HDAC1HPGDRAB9AHTTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114340672-A | Pharmaceutical composition comprising an HDAC inhibitor and an anti-PD 1 antibody or an anti-PD-L1 antibody | 晶体基因技术株式会社 | 2022-04-12 | — | — | CN | claimed |
| CN-112930177-B | Pharmaceutical compositions containing alkylcarbamoyl naphthoyl octenoyl hydroxyamide phosphate, tartrate or combinations thereof and methods of making the same | 晶体基因技术株式会社 | 2024-01-30 | — | — | CN | disclosed |
| CN-114340672-A | Pharmaceutical composition comprising an HDAC inhibitor and an anti-PD 1 antibody or an anti-PD-L1 antibody | 晶体基因技术株式会社 | 2022-04-12 | — | — | CN | disclosed |
| CN-110740989-B | Pharmaceutically acceptable salts of alkylcarbamoylnaphthoxyoctenoylhydroxyamides or derivatives thereof and process for preparing the same | 晶体基因技术株式会社 | 2022-03-08 | — | — | CN | disclosed |