Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1308418 | 0.91 | HPGD (0.56) | HPGDLMNAGAAMAPK1POLB | |
| SCHEMBL1308413 | 0.91 | HPGD (0.56) | HPGDLMNAGAAMAPK1POLB | |
| SCHEMBL1305983 | 0.89 | HPGD (0.59) | HPGDLMNAGAAMAPK1POLB | |
| SCHEMBL1305988 | 0.89 | HPGD (0.59) | HPGDLMNAGAAMAPK1POLB | |
| SCHEMBL1306245 | 0.84 | HPGD (0.49) | HPGDLMNAGAAMAPK1POLB | |
| SCHEMBL1305802 | 0.84 | GAA (0.47) | HPGDLMNAGAAPOLBRAB9A | |
| SCHEMBL1306801 | 0.82 | KDM4E (0.47) | HPGDLMNAGAAMAPK1POLB | |
| SCHEMBL1306509 | 0.82 | KMT2A (0.43) | HPGDLMNAGAAMAPK1RAB9A | |
| SCHEMBL1307038 | 0.81 | ALDH1A1 (0.51) | HPGDLMNAGAAMAPK1POLB | |
| SCHEMBL1307039 | 0.81 | ALDH1A1 (0.51) | HPGDLMNAGAAMAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |