Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | OGG1 | O15527 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1307250 | 0.92 | LMNA (0.52) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL1307248 | 0.92 | LMNA (0.52) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL1306677 | 0.91 | P2RX3 (0.47) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL1306672 | 0.91 | P2RX3 (0.47) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL1307207 | 0.86 | LMNA (0.43) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL1307099 | 0.85 | PTPN1 (0.48) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL1306692 | 0.85 | KMT2A (0.47) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL1307038 | 0.84 | ALDH1A1 (0.51) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL1307039 | 0.84 | ALDH1A1 (0.51) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL12113377 | 0.84 | ALDH1A1 (0.51) | KDM4EALDH1A1HPGDMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |