Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 9/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3804902 | 0.92 | MAP2K1 (0.62) | MAP2K1ALDH1A1MAP2K2CHEK1MAPK10 | |
| SCHEMBL3804582 | 0.90 | MAP2K1 (0.42) | MAP2K1ALDH1A1KDM4ETP53POLB | |
| SCHEMBL3809218 | 0.88 | ALOX15 (0.42) | MAP2K1ALDH1A1KDM4ETP53POLB | |
| SCHEMBL13063568 | 0.88 | MAP2K1 (0.46) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL3809196 | 0.87 | MAP2K1 (0.47) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL3800540 | 0.86 | MAP2K1 (0.45) | MAP2K1MAP2K2LMNACHEK1MAPK10 | |
| SCHEMBL3804513 | 0.85 | MAP2K1 (0.44) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL13063589 | 0.84 | MAP2K1 (0.43) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL3807711 | 0.84 | MAP2K1 (0.43) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL13063857 | 0.83 | MAP2K1 (0.43) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |