Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRD1 | O95696 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.38 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | KIF5B | P33176 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3806191 | 0.92 | MAP2K1 (0.48) | ALOX15TSHRALDH1A1TP53MAPT | |
| SCHEMBL13063574 | 0.88 | MAP2K1 (0.52) | ALOX15ALDH1A1KDM4ETP53LMNA | |
| SCHEMBL3806373 | 0.87 | ALOX15 (0.40) | ALOX15TSHRALDH1A1LMNAHTR6 | |
| SCHEMBL3807030 | 0.86 | ALOX15 (0.41) | ALOX15TSHRALDH1A1LMNAMAPT | |
| SCHEMBL13063605 | 0.84 | ALOX15 (0.42) | ALOX15TSHRALDH1A1LMNAMAPT | |
| SCHEMBL13063541 | 0.84 | ALOX15 (0.40) | ALOX15TSHRMAP2K1BRD4BRD1 | |
| SCHEMBL3808578 | 0.83 | ALOX15 (0.39) | ALOX15TSHRALDH1A1LMNAMAPT | |
| SCHEMBL13063826 | 0.82 | EGFR (0.38) | ALOX15TSHRMAP2K1EGFRRET | |
| SCHEMBL3808395 | 0.81 | ALOX15 (0.40) | ALOX15TSHRMAP2K1BRD4BRD1 | |
| SCHEMBL3804582 | 0.81 | MAP2K1 (0.42) | ALOX15TSHRALDH1A1KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |