Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 13/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.37 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4134490 | 0.89 | MAP2K1 (0.54) | MAP2K1TSHRBRAFMAP2K2MAP2K5 | |
| SCHEMBL13063815 | 0.89 | MAP2K1 (0.54) | MAP2K1TSHRKMT2ABRAFMAP2K2 | |
| SCHEMBL2701377 | 0.88 | MAP2K1 (0.68) | MAP2K1BRAFMAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL3811677 | 0.88 | MAP2K1 (0.41) | MAP2K1BRAFTHRB | |
| SCHEMBL3803502 | 0.84 | MAP2K1 (0.66) | MAP2K1BRAFMAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL3806030 | 0.84 | MAP2K1 (0.66) | MAP2K1BRAFMAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL13063592 | 0.84 | MAP2K1 (0.47) | MAP2K1ALOX15TSHRKMT2AMAP2K2 | |
| SCHEMBL486695 | 0.79 | MAP2K1 (0.57) | MAP2K1BRAFMAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL13063567 | 0.78 | MAP2K1 (0.47) | MAP2K1ALOX15TSHRMAP2K2MAP2K5 | |
| SCHEMBL15579605 | 0.78 | MAP2K1 (0.49) | MAP2K1ALOX15TSHRMAP2K2MAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673919-B2 | Dihydropyridin sulfonamides and dihydropyridin sulfamides as MEK inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |