Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 4/20 | 0.38 |
| ▸ | TSPO | P30536 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.38 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4134490 | 0.91 | MAP2K1 (0.54) | MAP2K1TSHRHSD17B10BRD4BRAF | |
| SCHEMBL2701377 | 0.89 | MAP2K1 (0.68) | MAP2K1BRAFMAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL13063766 | 0.89 | MAP2K1 (0.52) | MAP2K1TSHRBRAFMAP2K2MAP2K5 | |
| SCHEMBL3806030 | 0.85 | MAP2K1 (0.66) | MAP2K1BRD4BRAFMAP2K2MAP2K5 | |
| SCHEMBL3803502 | 0.85 | MAP2K1 (0.66) | MAP2K1BRAFMAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL3803495 | 0.83 | MAP2K1 (0.48) | MAP2K1TSHRHSD17B10TP53BRD4 | |
| SCHEMBL486695 | 0.80 | MAP2K1 (0.57) | MAP2K1BRAFMAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL3808726 | 0.79 | MAP2K1 (0.58) | MAP2K1TSHRHSD17B10PTGS2MAP2K2 | |
| SCHEMBL3811677 | 0.79 | MAP2K1 (0.41) | MAP2K1TP53BRD4BRAFSMN1; SMN2 | |
| SCHEMBL15579607 | 0.78 | MAP2K1 (0.54) | MAP2K1BRAFMAP2K2MAP2K5EIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |