Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.54 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | MRGPRX1 | Q96LB2 | 3/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.38 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.38 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13063815 | 0.91 | MAP2K1 (0.54) | MAP2K1BRAFMRGPRX1HRH1MAP2K2 | |
| SCHEMBL2701377 | 0.89 | MAP2K1 (0.68) | MAP2K1BRAFMAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL13063766 | 0.89 | MAP2K1 (0.52) | MAP2K1BRAFMAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL3806030 | 0.85 | MAP2K1 (0.66) | MAP2K1BRAFMAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL3803502 | 0.85 | MAP2K1 (0.66) | MAP2K1BRAFMAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL486695 | 0.80 | MAP2K1 (0.57) | MAP2K1BRAFMAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL12407095 | 0.79 | MRGPRX1 (0.51) | BRAFMRGPRX1HRH1KIT | |
| SCHEMBL3811677 | 0.79 | MAP2K1 (0.41) | MAP2K1BRAFBRPF1L3MBTL1BRD4 | |
| SCHEMBL15579607 | 0.78 | MAP2K1 (0.54) | MAP2K1BRAFMAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL9284438 | 0.77 | BRAF (0.48) | MAP2K1BRAFMRGPRX1HRH1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673919-B2 | Dihydropyridin sulfonamides and dihydropyridin sulfamides as MEK inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-20120107307-A1 | DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS | ARDEA BIOSCIENCES INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120107307-A1 | DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS | BRAF, NRAS, MAP3K12 | MAP2K1 59/4885BRAF 1/4885MRGPRX1 3028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.