Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.91 |
| ▸ | HPGD | P15428 | 3/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | PTGES | O14684 | 5/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13065007 | 0.93 | LMNA (0.86) | LMNAHPGDKMT2AGAAHTT | |
| SCHEMBL13065019 | 0.89 | LMNA (0.73) | LMNAHPGDKMT2AGAAHTT | |
| SCHEMBL303420 | 0.88 | LMNA (0.72) | LMNAHPGDKMT2AGAAPTGES | |
| SCHEMBL303307 | 0.88 | LMNA (0.71) | LMNAHPGDKMT2AGAAPTGES | |
| SCHEMBL3276606 | 0.87 | HPGD (0.71) | LMNAHPGDKMT2AGAAPTGES | |
| SCHEMBL304397 | 0.84 | HPGD (0.80) | LMNAHPGDKMT2APTGESALOX5 | |
| SCHEMBL3456953 | 0.84 | LMNA (0.79) | LMNAHPGDKMT2AGAAPTGES | |
| SCHEMBL303692 | 0.84 | LMNA (0.66) | LMNAHPGDKMT2AGAAHTT | |
| SCHEMBL303907 | 0.83 | LMNA (0.65) | LMNAHPGDKMT2AGAAPTGES | |
| SCHEMBL1711093 | 0.83 | LMNA (0.71) | LMNAHPGDKMT2AGAAPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130638-A1 | SULFONAMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | EVOTEC AG (DE) | 2010-11-18 | — | — | WO | disclosed |