Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.73 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | CTSG | P08311 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13065006 | 0.89 | LMNA (0.91) | LMNAHPGDKMT2AGAAHTT | |
| SCHEMBL13065007 | 0.82 | LMNA (0.86) | LMNAHPGDKMT2AGAAHTT | |
| SCHEMBL303692 | 0.78 | LMNA (0.66) | LMNAHPGDKMT2AGAAHTT | |
| SCHEMBL303420 | 0.77 | LMNA (0.72) | LMNAHPGDKMT2AGAAHTT | |
| SCHEMBL303307 | 0.77 | LMNA (0.71) | LMNAHPGDKMT2AGAAHTT | |
| SCHEMBL3276606 | 0.76 | HPGD (0.71) | LMNAHPGDKMT2AGAAHTT | |
| SCHEMBL304397 | 0.74 | HPGD (0.80) | LMNAHPGDKMT2AHTTSMN1; SMN2 | |
| SCHEMBL13065194 | 0.73 | HPGD (0.73) | LMNAHPGDKMT2AHTTSMN1; SMN2 | |
| SCHEMBL1711103 | 0.73 | HPGD (0.70) | LMNAHPGDKMT2AGAAHTT | |
| SCHEMBL303907 | 0.73 | LMNA (0.65) | LMNAHPGDKMT2AGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130638-A1 | SULFONAMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | EVOTEC AG (DE) | 2010-11-18 | — | — | WO | disclosed |