Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 5/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1305454 | 0.91 | P2RX3 (0.42) | P2RX3TRPM4ALDH1A1POLBG6PD | |
| SCHEMBL1307088 | 0.90 | P2RX3 (0.44) | P2RX3TRPM4ALDH1A1POLBG6PD | |
| SCHEMBL1306642 | 0.90 | P2RX3 (0.46) | P2RX3ALDH1A1POLBF10DRD4 | |
| SCHEMBL1306645 | 0.90 | P2RX3 (0.46) | P2RX3ALDH1A1POLBF10DRD4 | |
| SCHEMBL1306160 | 0.89 | KMT2A (0.45) | P2RX3TRPM4ALDH1A1POLBG6PD | |
| SCHEMBL1306974 | 0.85 | P2RX3 (0.54) | P2RX3ALDH1A1F10DRD4MAPT | |
| SCHEMBL1306977 | 0.85 | P2RX3 (0.54) | P2RX3ALDH1A1F10DRD4MAPT | |
| SCHEMBL1305883 | 0.80 | P2RX3 (0.48) | P2RX3ALDH1A1POLBKDM4EHPGD | |
| SCHEMBL1305888 | 0.80 | P2RX3 (0.48) | P2RX3ALDH1A1POLBKDM4EHPGD | |
| SCHEMBL1306169 | 0.79 | P2RX3 (0.51) | P2RX3ALDH1A1POLBDRD4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |