Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1305454 | 0.91 | P2RX3 (0.42) | KMT2AMEN1P2RX3ALDH1A1TRPM4 | |
| SCHEMBL1307088 | 0.89 | P2RX3 (0.44) | KMT2AMEN1P2RX3ALDH1A1TRPM4 | |
| SCHEMBL1306568 | 0.89 | P2RX3 (0.41) | KMT2AMEN1P2RX3ALDH1A1TRPM4 | |
| SCHEMBL1307933 | 0.87 | P2RX3 (0.51) | KMT2AMEN1P2RX3ALDH1A1TSHR | |
| SCHEMBL1307936 | 0.87 | P2RX3 (0.51) | KMT2AMEN1P2RX3ALDH1A1TSHR | |
| SCHEMBL1306159 | 0.85 | P2RX3 (0.50) | KMT2AMEN1P2RX3ALDH1A1TSHR | |
| SCHEMBL1306170 | 0.83 | ALDH1A1 (0.48) | ALDH1A1TSHRHPGDPOLBKDM4E | |
| SCHEMBL1306507 | 0.82 | P2RX3 (0.53) | KMT2AMEN1P2RX3ALDH1A1TSHR | |
| SCHEMBL1306511 | 0.82 | P2RX3 (0.53) | KMT2AMEN1P2RX3ALDH1A1TSHR | |
| SCHEMBL1306803 | 0.81 | HPGD (0.43) | KMT2AMEN1ALDH1A1TSHRTRPM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |