Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 5/20 | 0.34 |
| ▸ | CASP1 | P29466 | 4/20 | 0.34 |
| ▸ | CASP7 | P55210 | 4/20 | 0.34 |
| ▸ | CASP8 | Q14790 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | OGG1 | O15527 | 1/20 | 0.32 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1306583 | 1.00 | P2RX3 (0.46) | P2RX3CASP3CASP1CASP7CASP8 | |
| SCHEMBL1305810 | 0.87 | ALDH1A1 (0.37) | CASP3CASP1CASP7CASP8ALDH1A1 | |
| SCHEMBL1305816 | 0.87 | ALDH1A1 (0.37) | CASP3CASP1CASP7CASP8ALDH1A1 | |
| SCHEMBL1306987 | 0.86 | P2RX3 (0.47) | P2RX3CASP3CASP1CASP7CASP8 | |
| SCHEMBL1306988 | 0.86 | P2RX3 (0.47) | P2RX3CASP3CASP1CASP7CASP8 | |
| SCHEMBL1306580 | 0.85 | P2RX3 (0.47) | P2RX3ALDH1A1ADAMTS4ADAMTS5MEN1 | |
| SCHEMBL1305884 | 0.85 | ALDH1A1 (0.41) | CASP3CASP1CASP7CASP8ALDH1A1 | |
| SCHEMBL1306814 | 0.85 | CNR2 (0.38) | CASP3CASP1CASP7CASP8ALDH1A1 | |
| SCHEMBL1307999 | 0.83 | P2RX3 (0.62) | P2RX3CASP3CASP1CASP7CASP8 | |
| SCHEMBL1307169 | 0.82 | P2RX3 (0.55) | P2RX3ALDH1A1ADAMTS4ADAMTS5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2913322-A2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | Korea Research Institute Of Chemical Technology (KR) | 2015-09-02 | — | — | EP | disclosed |
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |
| US-20100069630-A1 | NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069630-A1 | NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | HDAC1, HDAC3, HDAC11 | P2RX3 4630/4885CASP3 542/4885CASP1 2439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.