Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.38 |
| ▸ | F10 | P00742 | 6/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PROC | P04070 | 1/20 | 0.37 |
| ▸ | KLK1 | P06870 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13065898 | 0.91 | PTGES (0.48) | PTGESSCN9AF10PRSS1PLG | |
| SCHEMBL2805076 | 0.84 | PTGES (0.52) | PTGESCA1CA2CA9 | |
| SCHEMBL2802214 | 0.84 | PTGES (0.47) | PTGESF10PRSS1PLGPROC | |
| SCHEMBL13066214 | 0.83 | PTGES (0.47) | PTGES | |
| SCHEMBL2802883 | 0.80 | PTGES (0.54) | PTGES | |
| SCHEMBL2803224 | 0.77 | PTGES (0.67) | PTGES | |
| SCHEMBL13066213 | 0.77 | PTGES (0.64) | PTGESSCN9AROCK2ROCK1CA9 | |
| SCHEMBL2806473 | 0.76 | PTGES (0.55) | PTGESCA1CA2CA9 | |
| SCHEMBL13065899 | 0.76 | PTGES (0.64) | PTGESCA1CA2CA9 | |
| SCHEMBL2802125 | 0.74 | PTGES (0.51) | PTGESF10PRSS1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292279-A1 | Bis-(Sulfonylamino) Derivatives in Therapy | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292279-A1 | Bis-(Sulfonylamino) Derivatives in Therapy | PTGER1, SULT2A1, SULT1E1 | PTGES 9/4885SCN9A 2169/4885F10 3420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.