Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 19/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 6/20 | 0.46 |
| ▸ | ADM2 | Q7Z4H4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13069034 | 0.87 | CALCRL (0.45) | CALCRLMAP2K2ADM2 | |
| SCHEMBL549050 | 0.74 | KMO (0.48) | CALCRLMAP2K2ADM2 | |
| SCHEMBL10246263 | 0.73 | CALCRL (0.59) | CALCRLMAP2K2ADM2 | |
| SCHEMBL12698621 | 0.71 | CALCRL (0.46) | CALCRLMAP2K2ADM2 | |
| SCHEMBL15401458 | 0.71 | CALCRL (0.46) | CALCRLMAP2K2ADM2 | |
| SCHEMBL15400764 | 0.71 | CALCRL (0.46) | CALCRLMAP2K2ADM2 | |
| SCHEMBL3044890 | 0.70 | CALCRL (0.44) | CALCRLMAP2K2ADM2 | |
| SCHEMBL13053403 | 0.70 | CALCRL (0.68) | CALCRLMAP2K2ADM2 | |
| SCHEMBL3750981 | 0.69 | CALCRL (0.66) | CALCRLMAP2K2 | |
| SCHEMBL3634241 | 0.69 | CALCRL (0.66) | CALCRLMAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225227-B1 | 1',3'-Dihydrospiro[imidazolidin-4,2'-inden]-2,5-diones and 1,3-dihydrospiro[inden-2,3']-pyrroles as CGRP antagonists | BOEHRINGER INGELHEIM INT (DE) | 2015-08-26 | — | — | EP | disclosed |
| EP-2251339-A2 | COMPOUNDS | Boehringer Ingelheim International GmbH (DE) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009065920-A2 | NOVEL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-05-28 | — | — | WO | disclosed |
| EP-2062889-A1 | Compounds | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2009-05-27 | — | — | EP | disclosed |