Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.34 |
| ▸ | ARNT | P27540 | 1/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3371424 | 1.00 | P2RX7 (0.35) | P2RX7CISD1ARNTEPAS1VNN1 | |
| SCHEMBL3370868 | 1.00 | P2RX7 (0.35) | P2RX7CISD1ARNTEPAS1VNN1 | |
| SCHEMBL3372598 | 0.89 | VNN1 (0.39) | VNN1ALDH1A1IDH1 | |
| SCHEMBL13069006 | 0.89 | VNN1 (0.39) | VNN1ALDH1A1IDH1 | |
| SCHEMBL3372593 | 0.89 | VNN1 (0.39) | VNN1ALDH1A1IDH1 | |
| SCHEMBL14337696 | 0.86 | MAP3K8 (0.38) | CISD1VNN1 | |
| SCHEMBL3371277 | 0.86 | MAP3K8 (0.38) | CISD1VNN1 | |
| SCHEMBL3371279 | 0.86 | MAP3K8 (0.38) | CISD1VNN1 | |
| SCHEMBL5573902 | 0.84 | PIK3CA (0.38) | P2RX7CISD1ARNTEPAS1 | |
| SCHEMBL5573899 | 0.84 | PIK3CA (0.38) | P2RX7CISD1ARNTEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869036-B1 | SUBSTITUTED 1,5-NAPHTHYRIDINE AZOLIDINONES AS CDK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2010-11-03 | — | — | EP | disclosed |
| US-7304074-B2 | Substituted 1,5-naphthyridine azolinones | HOFFMANN-LA ROCHE INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304074-B2 | Substituted 1,5-naphthyridine azolinones | HOFFMANN-LA ROCHE INC. (US) | 2007-12-04 | — | — | US | disclosed |