Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 14/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 13/20 | 0.39 |
| ▸ | MBTD1 | Q05BQ5 | 6/20 | 0.37 |
| ▸ | TP53BP1 | Q12888 | 3/20 | 0.37 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28012195 | 0.98 | MEN1 (0.41) | MEN1KMT2AL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL38657628 | 0.88 | MEN1 (0.47) | MEN1KMT2AL3MBTL3L3MBTL1 | |
| SCHEMBL17850483 | 0.88 | MEN1 (0.47) | MEN1KMT2AL3MBTL3L3MBTL1 | |
| SCHEMBL1306349 | 0.86 | MEN1 (0.44) | MEN1KMT2AL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL6029820 | 0.85 | MEN1 (0.41) | MEN1KMT2AKDM4E | |
| SCHEMBL1711612 | 0.84 | MEN1 (0.43) | MEN1KMT2AL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL28462314 | 0.84 | MEN1 (0.42) | MEN1KMT2AL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL28452884 | 0.82 | L3MBTL3 (0.41) | MEN1KMT2AL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL29266771 | 0.82 | MEN1 (0.41) | MEN1KMT2AL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL1307251 | 0.82 | ALDH1A1 (0.34) | L3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053457-B2 | 3-imidazolyl-indoles for the treatment of proliferative diseases | NOVARTIS AG (CH) | 2011-11-08 | — | — | US | claimed |
| US-20100125064-A1 | 3-Imidazolyl-Indoles for the Treatment of Proliferative Diseases | NOVARTIS AG (CH) | 2010-05-20 | — | — | US | claimed |
| EP-2142535-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Novartis Ag (CH) | 2010-01-13 | — | — | EP | claimed |
| WO-2008119741-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2008-10-09 | — | — | WO | claimed |
| US-8053457-B2 | 3-imidazolyl-indoles for the treatment of proliferative diseases | NOVARTIS AG (CH) | 2011-11-08 | — | — | US | disclosed |
| US-20100125064-A1 | 3-Imidazolyl-Indoles for the Treatment of Proliferative Diseases | NOVARTIS AG (CH) | 2010-05-20 | — | — | US | disclosed |
| EP-2142535-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Novartis Ag (CH) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008119741-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2008-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100125064-A1 | 3-Imidazolyl-Indoles for the Treatment of Proliferative Diseases | MDM4, TP53, MDM2 | MEN1 323/4885KMT2A 1471/4885L3MBTL3 279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.