Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3640846 | 0.73 | GRM5 (0.45) | TAAR1 | |
| SCHEMBL8094251 | 0.71 | ALDH1A1 (0.45) | P2RX7ALDH1A1TAAR1LMNAPOLB | |
| SCHEMBL2140667 | 0.71 | HSD11B1 (0.43) | — | |
| SCHEMBL363908 | 0.70 | — | — | |
| SCHEMBL29751863 | 0.70 | — | — | |
| SCHEMBL5527194 | 0.70 | TAAR1 (0.64) | DPP4ALDH1A1TAAR1 | |
| SCHEMBL9871992 | 0.70 | ALDH1A1 (0.43) | P2RX7ALDH1A1TAAR1LMNA | |
| SCHEMBL1290396 | 0.70 | ALDH1A1 (0.43) | P2RX7ALDH1A1TAAR1LMNA | |
| SCHEMBL10519032 | 0.70 | ALDH1A1 (0.43) | P2RX7ALDH1A1TAAR1LMNA | |
| SCHEMBL6963418 | 0.70 | TAAR1 (0.54) | DPP4TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888582-B1 | IMIDAZO- AND TRIAZOLOPYRIDINES AS INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I | BRISTOL MYERS SQUIBB CO (US) | 2010-11-10 | — | — | EP | disclosed |