Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 16/20 | 0.45 |
| ▸ | NOS1 | P29475 | 16/20 | 0.45 |
| ▸ | NMT2 | O60551 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 9/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1122146 | 0.84 | NOS3 (0.61) | NOS3NOS1NMT2NMT1APP | |
| SCHEMBL12305072 | 0.83 | NOS3 (0.66) | NOS3NOS1APPNOS2 | |
| SCHEMBL1122438 | 0.83 | NOS3 (0.66) | NOS3NOS1APPNOS2 | |
| SCHEMBL13846432 | 0.79 | NOS3 (0.49) | NOS3NOS1NOS2SLC6A2CYP3A4 | |
| SCHEMBL1122070 | 0.79 | NOS3 (0.65) | NOS3NOS1NOS2SLC6A2CYP3A4 | |
| SCHEMBL12857201 | 0.77 | NOS3 (0.52) | NOS3NOS1NOS2SLC6A2CYP3A4 | |
| SCHEMBL13849967 | 0.76 | NOS3 (0.65) | NOS3NOS1NOS2SLC6A2CYP3A4 | |
| SCHEMBL1122005 | 0.76 | HTR1D (0.64) | NOS3NOS1APPNOS2CYP3A4 | |
| SCHEMBL13846440 | 0.76 | NOS3 (0.65) | NOS3NOS1NOS2SLC6A2CYP3A4 | |
| SCHEMBL14507885 | 0.76 | NOS3 (0.42) | NOS3NOS1NMT2NMT1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1883451-B1 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON INC (CA) | 2010-11-24 | — | — | EP | disclosed |