Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | RBP4 | P02753 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10126863 | 0.81 | GAA (0.47) | GAAALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL16305327 | 0.81 | PDE3B (0.47) | GAASLC6A9ALDH1A1SMN1; SMN2HTR7 | |
| SCHEMBL22465912 | 0.81 | GAA (0.61) | GAASLC6A9ALDH1A1SMN1; SMN2HTR7 | |
| SCHEMBL29378218 | 0.81 | GAA (0.61) | GAASLC6A9ALDH1A1SMN1; SMN2HTR7 | |
| SCHEMBL10155964 | 0.79 | MAPT (0.44) | GAAALDH1A1SMN1; SMN2RBP4TTR | |
| SCHEMBL7818416 | 0.78 | ALDH1A1 (0.58) | GAASLC6A9ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL28901655 | 0.76 | SLC6A9 (0.48) | GAASLC6A9ALDH1A1SMN1; SMN2HTR7 | |
| Ammonia Solution, Strong SCHEMBL21245791 | 0.75 | GAA (0.42) | GAASLC6A9ALDH1A1SMN1; SMN2HTR7 | |
| SCHEMBL23538890 | 0.75 | ALDH1A1 (0.68) | GAASLC6A9ALDH1A1SMN1; SMN2HTR7 | |
| SCHEMBL21658082 | 0.75 | GAA (0.43) | GAAALDH1A1SMN1; SMN2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3009428-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2016-04-20 | — | — | EP | disclosed |
| EP-2428508-B9 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-04-20 | — | — | EP | disclosed |
| WO-2010128659-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | アステラス製薬株式会社 (JP) | 2010-11-11 | — | — | WO | disclosed |