Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.85 |
| ▸ | LMNA | P02545 | 2/20 | 0.85 |
| ▸ | MAPT | P10636 | 2/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | CA2 | P00918 | 4/20 | 0.58 |
| ▸ | CA1 | P00915 | 3/20 | 0.58 |
| ▸ | CA9 | Q16790 | 3/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.58 |
| ▸ | CA5A | P35218 | 1/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7271170 | 0.88 | SMN1; SMN2 (0.68) | SMN1; SMN2LMNAMAPTALDH1A1CA2 | |
| SCHEMBL7257961 | 0.86 | SMN1; SMN2 (0.66) | SMN1; SMN2LMNAMAPTALDH1A1CA2 | |
| SCHEMBL24970550 | 0.85 | SMN1; SMN2 (0.64) | SMN1; SMN2LMNAMAPTALDH1A1CA2 | |
| SCHEMBL20906409 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAMAPTALDH1A1CA2 | |
| SCHEMBL28195553 | 0.81 | HTT (0.75) | SMN1; SMN2LMNAMAPTALDH1A1HTT | |
| SCHEMBL2788591 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAMAPTALDH1A1CA2 | |
| SCHEMBL28003775 | 0.80 | SMN1; SMN2 (0.74) | SMN1; SMN2LMNAMAPTALDH1A1CA9 | |
| SCHEMBL29484286 | 0.79 | KDM4E (0.69) | SMN1; SMN2LMNAMAPTALDH1A1CA2 | |
| SCHEMBL1599701 | 0.79 | KDM4E (0.69) | SMN1; SMN2LMNAMAPTALDH1A1CA2 | |
| SCHEMBL6827507 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAMAPTALDH1A1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842705-B2 | Curcumin analogs with anti-tumor and anti-angiogenic properties | EMORY UNIVERSITY (US) | 2010-11-30 | — | — | US | disclosed |
| US-20080234320-A1 | CURCUMIN ANALOGS WITH ANTI-TUMOR AND ANTI-ANGIOGENIC PROPERTIES | EMORY UNIVERSITY | 2008-09-25 | — | — | US | disclosed |
| US-7371766-B2 | Curcumin analogs with anti-tumor and anti-angiogenic properties | EMORY UNIVERSITY (US) | 2008-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234320-A1 | CURCUMIN ANALOGS WITH ANTI-TUMOR AND ANTI-ANGIOGENIC PROPERTIES | PGF, VEGFA, VHL | SMN1; SMN2 4361/4885LMNA 2901/4885MAPT 3582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.