SCHEMBL24970550

SCHEMBL24970550

COc1ccc(CNS(C)(=N)=O)cc1OC

nearest known ligand 0.64

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.64
LMNA P02545 2/20 0.64
MAPT P10636 2/20 0.64
ALDH1A1 P00352 4/20 0.55
CA2 P00918 4/20 0.54
CA1 P00915 3/20 0.54
CA9 Q16790 3/20 0.54
CA12 O43570 2/20 0.54
CA5A P35218 1/20 0.54
CA14 Q9ULX7 1/20 0.54
CA4 P22748 1/20 0.50
HTT P42858 2/20 0.49
POLB P06746 2/20 0.49
KDM4E B2RXH2 2/20 0.49
TDP1 Q9NUW8 2/20 0.49
GAA P10253 1/20 0.49
PPARG P37231 1/20 0.47
PPARD Q03181 1/20 0.47
PPARA Q07869 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7271170 0.87 SMN1; SMN2 (0.68) SMN1; SMN2LMNAMAPTALDH1A1CA2
SCHEMBL13074347 0.85 SMN1; SMN2 (0.85) SMN1; SMN2LMNAMAPTALDH1A1CA2
SCHEMBL7257961 0.82 SMN1; SMN2 (0.66) SMN1; SMN2LMNAMAPTALDH1A1CA2
SCHEMBL20906409 0.78 SMN1; SMN2 (0.61) SMN1; SMN2LMNAMAPTALDH1A1CA2
SCHEMBL28195553 0.77 HTT (0.75) SMN1; SMN2LMNAMAPTALDH1A1HTT
SCHEMBL8681333 0.77 ALDH1A1 (0.63) SMN1; SMN2LMNAMAPTALDH1A1CA2
SCHEMBL28003775 0.76 SMN1; SMN2 (0.74) SMN1; SMN2LMNAMAPTALDH1A1CA9
SCHEMBL1599701 0.75 KDM4E (0.69) SMN1; SMN2LMNAMAPTALDH1A1CA2
SCHEMBL29484286 0.75 KDM4E (0.69) SMN1; SMN2LMNAMAPTALDH1A1CA2
SCHEMBL6827507 0.75 SMN1; SMN2 (0.57) SMN1; SMN2LMNAMAPTALDH1A1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4377312-A1 PESTICIDALLY ACTIVE FUSED BICYCLIC HETEROAROMATIC COMPOUNDS Syngenta Crop Protection AG (CH) 2024-06-05 EP disclosed
WO-2023006789-A1 PESTICIDALLY ACTIVE FUSED BICYCLIC HETEROAROMATIC COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-02-02 WO disclosed
WO-2023006789-A1 PESTICIDALLY ACTIVE FUSED BICYCLIC HETEROAROMATIC COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-02-02 WO disclosed