Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK2 | O95069 | 2/20 | 0.57 |
| ▸ | KCNK10 | P57789 | 2/20 | 0.57 |
| ▸ | MPO | P05164 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.51 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.47 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1308018 | 0.86 | NTRK1 (0.54) | KCNK2MPONTRK1NTRK2GRIK1 | |
| SCHEMBL1308660 | 0.85 | TMPRSS4 (0.64) | KCNK2KCNK10MPONTRK1AKR1C2 | |
| SCHEMBL1308286 | 0.84 | NPC1 (0.57) | KCNK2KCNK10AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL6351486 | 0.84 | KCNK2 (0.73) | KCNK2KCNK10MPOKDM1AAKR1C2 | |
| SCHEMBL6349454 | 0.84 | KCNK2 (0.56) | KCNK2KCNK10MPOKDM1AAKR1C2 | |
| SCHEMBL4823169 | 0.80 | SMN1; SMN2 (0.62) | NTRK1RXFP1TRPV1GPR27TMPRSS4 | |
| SCHEMBL1307972 | 0.80 | TP53 (0.70) | KCNK2KCNK10AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL6347825 | 0.80 | AKR1C2 (0.70) | KCNK2KCNK10MPOAKR1C2AKR1C1 | |
| SCHEMBL3853307 | 0.78 | SMN1; SMN2 (0.70) | TRPV1GPR27TMPRSS4MAPTNPC1 | |
| SCHEMBL6440422 | 0.77 | GRIK1 (0.62) | KCNK2KCNK10MPOKDM1AAKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042918-A1 | Pyridopyrimidinone Inhibitors of PIM-1 and/or PIM-3 | EXELIXIS, INC. (US) | 2009-02-12 | — | — | US | claimed |
| US-8053454-B2 | Pyridopyrimidinone inhibitors of PIM-1 and/or PIM-3 | EXELIXIS, INC. (US) | 2011-11-08 | — | — | US | disclosed |
| US-20090042918-A1 | Pyridopyrimidinone Inhibitors of PIM-1 and/or PIM-3 | EXELIXIS, INC. (US) | 2009-02-12 | — | — | US | disclosed |
| WO-2004022525-A1 | AMIDE DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2004-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042918-A1 | Pyridopyrimidinone Inhibitors of PIM-1 and/or PIM-3 | PIM1, PIM3, PIM2 | KCNK2 952/4885KCNK10 1098/4885MPO 3336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.