Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.64 |
| ▸ | SERPINE1 | P05121 | 4/20 | 0.58 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.57 |
| ▸ | KCNK10 | P57789 | 2/20 | 0.57 |
| ▸ | PPARG | P37231 | 3/20 | 0.56 |
| ▸ | PPARD | Q03181 | 2/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.56 |
| ▸ | MPO | P05164 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.53 |
| ▸ | PPARA | Q07869 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.51 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1308018 | 0.86 | NTRK1 (0.54) | TMPRSS4KCNK2MPONTRK1TRPV1 | |
| SCHEMBL1307435 | 0.85 | KCNK2 (0.57) | TMPRSS4KCNK2KCNK10MPONTRK1 | |
| SCHEMBL1308248 | 0.84 | TAS1R3 (0.65) | SERPINE1KCNK2KCNK10PPARGGRIK1 | |
| SCHEMBL18341193 | 0.81 | TMPRSS4 (0.85) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL418647 | 0.81 | SERPINE1 (0.66) | SERPINE1KCNK2KCNK10PPARGPPARD | |
| SCHEMBL19554129 | 0.81 | SERPINE1 (0.66) | SERPINE1KCNK2KCNK10PPARGPPARD | |
| SCHEMBL1307881 | 0.80 | KCNMA1 (0.68) | SERPINE1PPARGGRIK1PPARAKDM4E | |
| SCHEMBL330166 | 0.78 | TMPRSS4 (1.00) | TMPRSS4TRPV1P2RX1P2RX4P2RX7 | |
| SCHEMBL14855607 | 0.78 | KCNMA1 (0.65) | SERPINE1GRIK1KDM4EHSD17B10AKR1C4 | |
| SCHEMBL14113139 | 0.78 | TMPRSS4 (0.64) | TMPRSS4NTRK1TRPV1NTRK2P2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042918-A1 | Pyridopyrimidinone Inhibitors of PIM-1 and/or PIM-3 | EXELIXIS, INC. (US) | 2009-02-12 | — | — | US | claimed |
| US-8053454-B2 | Pyridopyrimidinone inhibitors of PIM-1 and/or PIM-3 | EXELIXIS, INC. (US) | 2011-11-08 | — | — | US | disclosed |
| US-20090042918-A1 | Pyridopyrimidinone Inhibitors of PIM-1 and/or PIM-3 | EXELIXIS, INC. (US) | 2009-02-12 | — | — | US | disclosed |
| WO-2004022525-A1 | AMIDE DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2004-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042918-A1 | Pyridopyrimidinone Inhibitors of PIM-1 and/or PIM-3 | PIM1, PIM3, PIM2 | TMPRSS4 3632/4885SERPINE1 2130/4885KCNK2 952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.