Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.56 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.52 |
| ▸ | RORC | P51449 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | XBP1 | P17861 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4823169 | 0.91 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL3851218 | 0.85 | RAB9A (0.78) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL6370502 | 0.84 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL17845892 | 0.83 | TMPRSS4 (0.80) | SMN1; SMN2NPC1RAB9AKMT2ATMPRSS4 | |
| SCHEMBL30771749 | 0.83 | TMPRSS4 (0.80) | SMN1; SMN2NPC1RAB9AKMT2ATMPRSS4 | |
| SCHEMBL3846318 | 0.82 | KMT2A (0.65) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL12334376 | 0.82 | RORC (0.65) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL17845904 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL8111907 | 0.80 | JAK2 (0.69) | GPR27TRPV1P2RX1L3MBTL1 | |
| SCHEMBL678096 | 0.80 | PTGS1 (0.64) | SMN1; SMN2LMNAKMT2AGPR27TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |