Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.32 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ERN1 | O75460 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13074492 | 1.00 | MCHR1 (0.33) | MCHR1KCNH2MCHR2NAMPTALOX5 | |
| SCHEMBL1119805 | 0.90 | CCR2 (0.39) | KCNH2 | |
| SCHEMBL1119826 | 0.90 | CCR2 (0.39) | KCNH2 | |
| SCHEMBL1119807 | 0.90 | CCR2 (0.39) | KCNH2 | |
| SCHEMBL13809767 | 0.89 | SMN1; SMN2 (0.36) | MCHR1KCNH2MCHR2NAMPTSSTR5 | |
| SCHEMBL13809765 | 0.89 | SMN1; SMN2 (0.36) | MCHR1KCNH2MCHR2NAMPTSSTR5 | |
| SCHEMBL15353819 | 0.87 | KCNJ1 (0.32) | MCHR1NAMPTLMNATSHR | |
| SCHEMBL15353818 | 0.87 | KCNJ1 (0.32) | MCHR1NAMPTLMNATSHR | |
| SCHEMBL15353817 | 0.87 | KCNJ1 (0.32) | MCHR1NAMPTLMNATSHR | |
| SCHEMBL13011606 | 0.85 | CCR2 (0.39) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129843-A1 | DIHYDRONAPHTHYRIDINYL AND RELATED COMPOUNDS FOR USE IN TREATING OPHTHALMOLOGICAL DISORDERS | CYTOPATHFINDER, INC. (JP) | 2010-11-11 | — | — | WO | disclosed |
| WO-2009076512-A1 | CARBOXAMIDΞ COMPOUNDS AND THEIR USE AS CHEMOKINE RECEPTOR AGONISTS | EPIX DELAWARE, INC. (US) | 2009-06-18 | — | — | WO | disclosed |