Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.39 |
| ▸ | HTR3B | O95264 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17531091 | 0.81 | NPC1 (0.42) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL10030527 | 0.78 | CYP2C9 (0.44) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL1405393 | 0.78 | NPC1 (0.61) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL11693067 | 0.78 | NPC1 (0.61) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL11693056 | 0.78 | NPC1 (0.61) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL255052 | 0.78 | NPC1 (0.61) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL17446281 | 0.78 | NPC1 (0.61) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL23691126 | 0.77 | ALDH1A1 (0.55) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL10153008 | 0.77 | ALDH1A1 (0.55) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL12677158 | 0.77 | ALDH1A1 (0.55) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100285605-A1 | Neurofibrillary labels | WISTA LABORATORIES LTD. | 2010-11-11 | — | — | US | disclosed |
| US-7713962-B2 | Neurofibrillary labels | WISTA LABORATORIES LTD. (SG) | 2010-05-11 | — | — | US | disclosed |
| US-20080219929-A1 | Neurofibrillary labels | WISTA LABORATORIES, LTD. | 2008-09-11 | — | — | US | disclosed |
| US-7335652-B2 | Neurofibrillary labels | WISTA LABORATORIES LTD. (SG) | 2008-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080219929-A1 | Neurofibrillary labels | MAPT, PSEN1, PSEN2 | NPC1 3325/4885RAB9A 2505/4885MAPT 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.