Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 18/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1119838 | 0.93 | CCR2 (0.42) | CCR2KCNH2CYP3A4 | |
| SCHEMBL1120051 | 0.90 | CCR2 (0.41) | CCR2KCNH2 | |
| SCHEMBL13074912 | 0.88 | CCR2 (0.36) | CCR2KCNH2CYP2D6CYP3A4 | |
| SCHEMBL1119890 | 0.85 | CCR2 (0.42) | CCR2KCNH2 | |
| SCHEMBL3742106 | 0.85 | CCR2 (0.42) | CCR2KCNH2 | |
| SCHEMBL3735950 | 0.85 | CCR2 (0.42) | CCR2KCNH2 | |
| SCHEMBL13074450 | 0.84 | CCR2 (0.37) | CCR2KCNH2 | |
| SCHEMBL1119974 | 0.82 | CCR2 (0.40) | CCR2KCNH2 | |
| SCHEMBL1120009 | 0.82 | CCR2 (0.39) | CCR2KCNH2 | |
| SCHEMBL13074448 | 0.79 | CCR2 (0.35) | CCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129843-A1 | DIHYDRONAPHTHYRIDINYL AND RELATED COMPOUNDS FOR USE IN TREATING OPHTHALMOLOGICAL DISORDERS | CYTOPATHFINDER, INC. (JP) | 2010-11-11 | — | — | WO | disclosed |
| WO-2009076512-A1 | CARBOXAMIDΞ COMPOUNDS AND THEIR USE AS CHEMOKINE RECEPTOR AGONISTS | EPIX DELAWARE, INC. (US) | 2009-06-18 | — | — | WO | disclosed |