Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.34 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.34 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL113504 | 0.79 | BRD4 (0.39) | BRD4MKNK1MKNK2TRPA1MEN1 | |
| SCHEMBL9942645 | 0.72 | MKNK1 (0.38) | BRD4MKNK1MKNK2CCNKCDK12 | |
| SCHEMBL21847766 | 0.72 | MKNK1 (0.38) | BRD4MKNK1MKNK2MEN1KMT2A | |
| SCHEMBL29424856 | 0.69 | TRPA1 (0.57) | TRPA1DRD1 | |
| SCHEMBL21988108 | 0.69 | TRPA1 (0.57) | TRPA1DRD1 | |
| SCHEMBL113847 | 0.68 | PRKCQ (0.41) | TRPA1DRD1 | |
| SCHEMBL1473221 | 0.67 | BRD4 (0.40) | BRD4MKNK1MKNK2MEN1KMT2A | |
| SCHEMBL27290679 | 0.67 | AXL (0.42) | BRD4MKNK1MKNK2CCNKCDK12 | |
| SCHEMBL2628910 | 0.67 | AXL (0.42) | BRD4MKNK1MKNK2CCNKCDK12 | |
| SCHEMBL14329063 | 0.66 | TTBK1 (0.38) | BRD4CDK2JAK3TTBK1TTBK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125402-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2010-11-04 | — | — | WO | disclosed |