Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13075627 | 0.94 | PTGES (0.47) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL13075618 | 0.93 | ADORA3 (0.46) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL13075620 | 0.89 | ADORA3 (0.44) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL3792792 | 0.86 | PTGES (0.43) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL13075934 | 0.86 | PTGES (0.42) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL13075932 | 0.85 | PTGES (0.41) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL13075940 | 0.85 | PTGES (0.41) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL13075935 | 0.84 | NPC1 (0.41) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL13075938 | 0.84 | PTGES (0.40) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL13075930 | 0.83 | PTGES (0.40) | NPC1RAB9ACASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |