Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | QPCT | Q16769 | 4/20 | 0.45 |
| ▸ | CDK4 | P11802 | 3/20 | 0.44 |
| ▸ | CCND1 | P24385 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.44 |
| ▸ | CCND3 | P30281 | 2/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 4/20 | 0.44 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.43 |
| ▸ | MELK | Q14680 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13076278 | 0.89 | IP6K1 (0.41) | KDM4EMAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL37877089 | 0.79 | MEN1 (0.58) | KDM4EMAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL27517100 | 0.78 | IP6K1 (0.64) | KDM4EMAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL23123445 | 0.78 | VCP (0.47) | KDM4EMAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL29745017 | 0.78 | VCP (0.47) | KDM4EMAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL20259978 | 0.77 | L3MBTL3 (0.54) | QPCTIP6K1IP6K3 | |
| SCHEMBL22001349 | 0.77 | IP6K1 (0.49) | KDM4EMAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL18108512 | 0.77 | PIK3CA (0.63) | KDM4EMAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL23123960 | 0.76 | QPCT (0.54) | KDM4EMAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL20644661 | 0.74 | KDM4E (0.52) | KDM4EMAPTALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125402-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2010-11-04 | — | — | WO | disclosed |