Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 4/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 8/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3797531 | 0.80 | TRPA1 (0.68) | TRPA1TRPV4 | |
| SCHEMBL14376673 | 0.76 | TRPA1 (0.68) | TRPA1MEN1KMT2ATRPV4ROCK1 | |
| SCHEMBL12292216 | 0.75 | TRPA1 (0.50) | TRPA1TRPV4 | |
| SCHEMBL1799679 | 0.74 | TRPA1 (0.61) | TRPA1MEN1KMT2ATRPV4ROCK1 | |
| SCHEMBL13076331 | 0.69 | TRPA1 (0.67) | TRPA1TRPV4 | |
| SCHEMBL13076673 | 0.67 | TRPA1 (0.77) | TRPA1TRPV4 | |
| SCHEMBL13075960 | 0.67 | TRPA1 (0.69) | TRPA1TRPV4 | |
| SCHEMBL7041676 | 0.66 | NPC1 (0.60) | MEN1KMT2AMAPTRAB9A | |
| SCHEMBL13076875 | 0.66 | TRPA1 (0.65) | TRPA1TRPV4 | |
| SCHEMBL10178209 | 0.66 | MAPT (0.74) | TRPA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125469-A1 | PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-11-04 | — | — | WO | disclosed |