Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 16/20 | 0.68 |
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.51 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14227850 | 0.81 | TRPA1 (1.00) | TRPA1TRPV4 | |
| SCHEMBL14479318 | 0.79 | TRPA1 (0.77) | TRPA1TRPV4 | |
| SCHEMBL1800120 | 0.77 | TRPA1 (1.00) | TRPA1TRPV4 | |
| SCHEMBL480652 | 0.76 | TRPA1 (0.59) | TRPA1ELOVL1MEN1RAB9AKMT2A | |
| SCHEMBL13076288 | 0.76 | WNT3A (0.46) | TRPA1TRPV4ELOVL1MEN1RAB9A | |
| SCHEMBL14672007 | 0.76 | TRPA1 (0.71) | TRPA1TRPV4 | |
| SCHEMBL611898 | 0.73 | TRPA1 (0.76) | TRPA1TRPV4 | |
| SCHEMBL13076673 | 0.73 | TRPA1 (0.77) | TRPA1TRPV4 | |
| SCHEMBL10275045 | 0.73 | TRPA1 (0.90) | TRPA1TRPV4 | |
| SCHEMBL13174929 | 0.72 | TRPA1 (0.79) | TRPA1TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012176143-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A TRPA1 ANTAGONIST AND A BETA-2 AGONIST | GLENMARK PHARMACEUTICALS SA (CH) | 2012-12-27 | — | — | WO | disclosed |
| WO-2012176105-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A TRPA1 ANTAGONIST AND A LEUKOTRIENE RECEPTOR ANTAGONIST | GLENMARK PHARMACEUTICALS SA (CH) | 2012-12-27 | — | — | WO | disclosed |