Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 1/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 9/20 | 0.54 |
| ▸ | TRPV4 | Q9HBA0 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 8/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13076680 | 0.91 | TRPA1 (0.67) | TRPA1TRPV4 | |
| SCHEMBL13076323 | 0.91 | TRPA1 (0.56) | TRPA1TRPV4MEN1KMT2ARAB9A | |
| SCHEMBL13076890 | 0.91 | TRPA1 (0.62) | TRPA1TRPV4 | |
| SCHEMBL13075973 | 0.90 | TRPA1 (0.61) | TRPA1TRPV4 | |
| SCHEMBL13076682 | 0.89 | TRPA1 (0.68) | TRPA1TRPV4 | |
| SCHEMBL13075853 | 0.89 | TRPA1 (0.54) | TRPA1TRPV4MAPT | |
| SCHEMBL13076881 | 0.86 | TRPA1 (0.56) | TRPA1TRPV4 | |
| SCHEMBL13075969 | 0.86 | TRPA1 (0.62) | TRPA1TRPV4 | |
| SCHEMBL13076878 | 0.84 | TRPA1 (0.67) | TRPA1TRPV4 | |
| SCHEMBL13075862 | 0.84 | TRPA1 (0.62) | TRPA1TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125469-A1 | PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-11-04 | — | — | WO | disclosed |