Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 14/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13076876 | 0.89 | WNT3A (0.56) | TRPA1MAPTTRPV4 | |
| SCHEMBL13076881 | 0.87 | TRPA1 (0.56) | TRPA1TRPV4 | |
| SCHEMBL13075969 | 0.87 | TRPA1 (0.62) | TRPA1TRPV4 | |
| SCHEMBL13076890 | 0.86 | TRPA1 (0.62) | TRPA1TRPV4 | |
| SCHEMBL13076878 | 0.85 | TRPA1 (0.67) | TRPA1TRPV4 | |
| SCHEMBL13075862 | 0.85 | TRPA1 (0.62) | TRPA1TRPV4 | |
| SCHEMBL13076680 | 0.84 | TRPA1 (0.67) | TRPA1TRPV4 | |
| SCHEMBL13076323 | 0.84 | TRPA1 (0.56) | TRPA1TRPV4 | |
| SCHEMBL13076884 | 0.84 | ALDH1A1 (0.47) | TRPA1MAPTRORC | |
| SCHEMBL13075973 | 0.84 | TRPA1 (0.61) | TRPA1TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125469-A1 | PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-11-04 | — | — | WO | disclosed |