Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 19/20 | 0.84 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL117859 | 0.91 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117858 | 0.91 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117451 | 0.91 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117452 | 0.91 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117641 | 0.89 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117639 | 0.89 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| Nitrous Acid SCHEMBL15949377 | 0.89 | HSD11B1 (0.83) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117640 | 0.89 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL116334 | 0.86 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL116333 | 0.86 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127237-A2 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010011314-A1 | CYCLIC INHIBITORS OF 11 BETA-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2009134400-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-11-05 | — | — | WO | disclosed |