Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 20/20 | 0.83 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL117858 | 0.91 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117859 | 0.91 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL13077091 | 0.89 | HSD11B1 (0.84) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL15241449 | 0.87 | HSD11B1 (0.86) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117640 | 0.87 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117641 | 0.87 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117639 | 0.87 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL116334 | 0.85 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL116333 | 0.85 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL590318 | 0.85 | HSD11B1 (0.79) | HSD11B1CYP2C9CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183228-B1 | CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 | VITAE PHARMACEUTICALS INC (US) | 2014-08-20 | — | — | EP | disclosed |