Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 5/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.62 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ESRRA | P11474 | 1/20 | 0.32 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | PTPRC | P08575 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | F2R | P25116 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13077479 | 0.90 | ADRB2 (0.64) | ADRB2ADRB1SLC22A1LMNAHIF1A | |
| SCHEMBL13077699 | 0.88 | ADRB2 (0.49) | ADRB2ADRB1SLC22A1LMNAHIF1A | |
| SCHEMBL13040051 | 0.88 | ADRB2 (0.60) | ADRB2ADRB1SLC22A1LMNAHIF1A | |
| SCHEMBL13077500 | 0.84 | ADRB2 (0.62) | ADRB2ADRB1SLC22A1LMNAHIF1A | |
| SCHEMBL13040049 | 0.79 | LMNA (0.62) | ADRB2ADRB1SLC22A1LMNAHIF1A | |
| SCHEMBL13077701 | 0.79 | ADRB2 (0.59) | ADRB2ADRB1SLC22A1LMNAHIF1A | |
| SCHEMBL13077501 | 0.78 | LMNA (0.51) | ADRB2ADRB1SLC22A1LMNAHIF1A | |
| Acebutolol SCHEMBL5360413 | 0.77 | ADRB2 (1.00) | ADRB2ADRB1SLC22A1LMNAHIF1A | |
| Acebutolol SCHEMBL3772 | 0.77 | ADRB2 (1.00) | ADRB2ADRB1SLC22A1LMNAHIF1A | |
| Acebutolol SCHEMBL5360409 | 0.77 | ADRB2 (1.00) | ADRB2ADRB1SLC22A1LMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825263-B2 | Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive | NICOX S.A. (FR) | 2010-11-02 | — | — | US | disclosed |