Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 4/20 | 0.38 |
| ▸ | STS | P08842 | 5/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6462748 | 0.90 | LMNA (0.52) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL6569575 | 0.90 | LMNA (0.52) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL13079251 | 0.85 | ESR1 (0.46) | LMNAHSD17B1MAPTKDM4EHSD17B10 | |
| SCHEMBL3750468 | 0.85 | HSD17B1 (0.47) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL8366649 | 0.80 | LMNA (0.69) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL2760327 | 0.80 | LMNA (0.69) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL21276838 | 0.80 | LMNA (0.69) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL6462744 | 0.79 | LMNA (0.44) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL6535977 | 0.77 | HSD17B1 (0.67) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL14421698 | 0.77 | HSD17B1 (0.67) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838516-B2 | 15 β-substituted steroids having selective estrogenic activity | N.V. ORGANON (NL) | 2010-11-23 | — | — | US | disclosed |
| US-20070254860-A1 | 15 Beta-Substituted Steroids Having Selective Estrogenic Activity | N.V. ORGANON (NL) | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254860-A1 | 15 Beta-Substituted Steroids Having Selective Estrogenic Activity | HSD17B11, ESR2, CYP19A1 | LMNA 2504/4885HSD17B1 15/4885MAPT 4868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.