Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13082268 | 0.89 | CYP1A2 (0.36) | ALDH1A1L3MBTL1MAPK14FAAHNPC1 | |
| SCHEMBL13057448 | 0.82 | MAPK14 (0.55) | ALDH1A1L3MBTL1MAPK14NPC1CYP1A2 | |
| SCHEMBL13057462 | 0.82 | MAPK14 (0.50) | ALDH1A1L3MBTL1MAPK14NPC1RAB9A | |
| SCHEMBL13082262 | 0.78 | PTGDR2 (0.33) | FAAHAPLNRPDE5ACLK1 | |
| SCHEMBL13057452 | 0.78 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1NPC1RAB9AXBP1 | |
| SCHEMBL13082200 | 0.75 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1NPC1RAB9ACLK1 | |
| SCHEMBL13057451 | 0.71 | MAPK14 (0.44) | ALDH1A1L3MBTL1MAPK14CYP1A2CYP2C9 | |
| SCHEMBL7826439 | 0.70 | FAAH (0.47) | ALDH1A1L3MBTL1MAPK14FAAHRAB9A | |
| SCHEMBL13057455 | 0.69 | ALDH1A1 (0.46) | ALDH1A1NPC1RAB9A | |
| SCHEMBL8070679 | 0.68 | CREBBP (0.41) | ALDH1A1L3MBTL1NPC1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426595-B2 | Gamma secretase modulators | MERCK SHARP & DOHME LLC | 2013-04-23 | — | — | US | disclosed |
| US-20100297128-A1 | GAMMA SECRETASE MODULATORS | MERCK SHARP & DOHME LLC | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100297128-A1 | GAMMA SECRETASE MODULATORS | BACE1, BACE2, PSEN1 | ALDH1A1 1882/4885L3MBTL1 4429/4885MAPK14 3638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.