Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | NCF1 | P14598 | 9/20 | 0.47 |
| ▸ | APP | P05067 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19480349 | 0.84 | KDM4E (0.47) | MAPK1NCF1APPL3MBTL1KDM4E | |
| SCHEMBL17030281 | 0.84 | MAPK1 (0.61) | MAPK1APPL3MBTL1KDM4ENPC1 | |
| SCHEMBL17030243 | 0.84 | MAPK1 (0.61) | MAPK1APPL3MBTL1KDM4ENPC1 | |
| SCHEMBL17030289 | 0.83 | MAPK1 (0.60) | MAPK1APPL3MBTL1KDM4ENPC1 | |
| SCHEMBL12986982 | 0.82 | MAPK1 (0.52) | MAPK1APPL3MBTL1KDM4ENPC1 | |
| SCHEMBL17030247 | 0.77 | MAPK1 (0.42) | MAPK1APPL3MBTL1KDM4ENPC1 | |
| SCHEMBL4698769 | 0.75 | BCHE (0.54) | MAPK1ALDH1A1MAPTHPGDPIK3CA | |
| SCHEMBL12979981 | 0.74 | MAPK1 (0.70) | MAPK1L3MBTL1ALDH1A1PIK3CAMAPK8 | |
| SCHEMBL13083328 | 0.74 | SMN1; SMN2 (0.46) | MAPK1APPKDM4ENPC1ALDH1A1 | |
| SCHEMBL13191745 | 0.72 | NPC1 (0.47) | MAPK1L3MBTL1KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012136691-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | ÆTERNA ZENTARIS GMBH (DE) | 2012-10-11 | — | — | WO | disclosed |
| EP-2508184-A1 | Pyridopyrazine derivatives and their use | Æterna Zentaris GmbH (DE) | 2012-10-10 | — | — | EP | disclosed |