Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | BCHE | P06276 | 3/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 6/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13083333 | 0.82 | MAPK1 (0.53) | MAPK1NPC1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL17030281 | 0.80 | MAPK1 (0.61) | MAPK1NPC1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL17030243 | 0.80 | MAPK1 (0.61) | MAPK1NPC1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL17030289 | 0.79 | MAPK1 (0.60) | MAPK1NPC1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL9908948 | 0.74 | BCHE (0.65) | MAPK1NPC1MAPTSMN1; SMN2BCHE | |
| SCHEMBL4613135 | 0.72 | L3MBTL1 (0.61) | MAPK1SMN1; SMN2KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL466232 | 0.72 | APP (0.65) | MAPK1SMN1; SMN2KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL9908947 | 0.71 | BCHE (0.57) | MAPK1NPC1MAPTSMN1; SMN2BCHE | |
| SCHEMBL23143409 | 0.71 | BCHE (0.60) | MAPK1NPC1SMN1; SMN2BCHEACHE | |
| SCHEMBL31440926 | 0.70 | ATP4A (0.59) | MAPK1NPC1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694067-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | Æterna Zentaris GmbH (DE) | 2014-02-12 | — | — | EP | disclosed |
| WO-2012136691-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | ÆTERNA ZENTARIS GMBH (DE) | 2012-10-11 | — | — | WO | disclosed |