Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 13/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17030243 | 1.00 | MAPK1 (0.61) | MAPK1L3MBTL1PIK3CAMAPK8MAPK9 | |
| SCHEMBL17030289 | 0.90 | MAPK1 (0.60) | MAPK1L3MBTL1PIK3CAMAPK8MAPK9 | |
| SCHEMBL13083333 | 0.84 | MAPK1 (0.53) | MAPK1L3MBTL1PIK3CAMAPK8MAPK9 | |
| SCHEMBL12979981 | 0.81 | MAPK1 (0.70) | MAPK1L3MBTL1PIK3CAMAPK8MAPK9 | |
| SCHEMBL12986982 | 0.80 | MAPK1 (0.52) | MAPK1L3MBTL1KDM4ENPC1ALDH1A1 | |
| SCHEMBL17030269 | 0.79 | MAPK1 (0.77) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL12979984 | 0.79 | MAPK1 (0.57) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL17030254 | 0.78 | MAPK1 (0.46) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL17030249 | 0.77 | MAPK1 (0.67) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL12970822 | 0.77 | MAPK1 (1.00) | MAPK1PIK3CAMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694067-B1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | TERNA ZENTARIS GMBH (DE) | 2015-08-26 | — | — | EP | disclosed |