Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.62 |
| ▸ | KCNK10 | P57789 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.60 |
| ▸ | F10 | P00742 | 1/20 | 0.57 |
| ▸ | PRSS12 | P56730 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1308714 | 0.87 | MEN1 (0.76) | KMT2AMEN1PKMNPSR1GRIK1 | |
| SCHEMBL3785256 | 0.86 | F10 (0.77) | KMT2AMEN1PKMNPSR1ALDH1A1 | |
| SCHEMBL13941747 | 0.86 | MEN1 (0.75) | KMT2AMEN1PKMNPSR1GRIK1 | |
| SCHEMBL6351589 | 0.86 | KMT2A (0.75) | KMT2AMEN1PKMNPSR1ALDH1A1 | |
| SCHEMBL1310106 | 0.83 | GRIK1 (0.74) | KMT2AMEN1PKMNPSR1GRIK1 | |
| SCHEMBL3962093 | 0.83 | GRIK1 (1.00) | KMT2AMEN1PKMNPSR1GRIK1 | |
| SCHEMBL2935687 | 0.82 | MEN1 (0.69) | KMT2AMEN1PKMNPSR1GRIK1 | |
| SCHEMBL2269165 | 0.82 | MEN1 (0.69) | KMT2AMEN1PKMNPSR1ALDH1A1 | |
| SCHEMBL2271007 | 0.82 | MEN1 (0.69) | KMT2AMEN1PKMNPSR1MAPT | |
| SCHEMBL11228267 | 0.82 | MEN1 (0.69) | KMT2AMEN1PKMNPSR1GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042918-A1 | Pyridopyrimidinone Inhibitors of PIM-1 and/or PIM-3 | EXELIXIS, INC. (US) | 2009-02-12 | — | — | US | claimed |
| US-8053454-B2 | Pyridopyrimidinone inhibitors of PIM-1 and/or PIM-3 | EXELIXIS, INC. (US) | 2011-11-08 | — | — | US | disclosed |
| US-20090042918-A1 | Pyridopyrimidinone Inhibitors of PIM-1 and/or PIM-3 | EXELIXIS, INC. (US) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042918-A1 | Pyridopyrimidinone Inhibitors of PIM-1 and/or PIM-3 | PIM1, PIM3, PIM2 | KMT2A 1570/4885MEN1 2312/4885PKM 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.