Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.75 |
| ▸ | PKM | P14618 | 1/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | PLK1 | P53350 | 2/20 | 0.58 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.58 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1307943 | 0.90 | SERPINE1 (0.70) | MEN1KMT2APKMNPSR1SMN1; SMN2 | |
| SCHEMBL14075266 | 0.87 | PLK1 (0.78) | MEN1KMT2APKMNPSR1SMN1; SMN2 | |
| SCHEMBL1308442 | 0.86 | KMT2A (1.00) | MEN1KMT2APKMNPSR1RAB9A | |
| SCHEMBL1308714 | 0.84 | MEN1 (0.76) | MEN1KMT2APKMNPSR1SMN1; SMN2 | |
| SCHEMBL14075222 | 0.81 | SERPINE1 (0.67) | MEN1KMT2APKMNPSR1SMN1; SMN2 | |
| SCHEMBL1310106 | 0.80 | GRIK1 (0.74) | MEN1KMT2APKMNPSR1KCNK2 | |
| SCHEMBL14075264 | 0.79 | PLK1 (0.69) | MEN1KMT2APKMNPSR1SMN1; SMN2 | |
| SCHEMBL1309321 | 0.79 | MEN1 (0.70) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14075268 | 0.78 | PLK1 (0.75) | MEN1KMT2APKMNPSR1PLK1 | |
| SCHEMBL1307133 | 0.78 | MEN1 (0.68) | MEN1KMT2APKMNPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009018084-A1 | SMALL MOLECULE INHIBITORS OF RNA SILENCING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-02-05 | — | — | WO | disclosed |
| US-7429677-B2 | Small molecule entry inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-09-30 | — | — | US | disclosed |
| US-7429677-B2 | Small molecule entry inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-09-30 | — | — | US | disclosed |