Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | PER2 | O15055 | 2/20 | 0.34 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 3/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13036413 | 1.00 | PTGER3 (0.38) | PTGER3HSD11B1PER2CRY2MCHR1 | |
| SCHEMBL13036412 | 1.00 | PTGER3 (0.38) | PTGER3HSD11B1PER2CRY2MCHR1 | |
| SCHEMBL13084696 | 0.96 | HSD11B1 (0.36) | PTGER3HSD11B1PER2CRY2MCHR1 | |
| SCHEMBL13036385 | 0.96 | HSD11B1 (0.36) | PTGER3HSD11B1PER2CRY2MCHR1 | |
| SCHEMBL13036382 | 0.96 | HSD11B1 (0.36) | PTGER3HSD11B1PER2CRY2MCHR1 | |
| SCHEMBL13036360 | 0.87 | ADRA1A (0.38) | PTGER3HSD11B1PER2CRY2TACR1 | |
| SCHEMBL13036361 | 0.87 | ADRA1A (0.38) | PTGER3HSD11B1PER2CRY2TACR1 | |
| SCHEMBL13084648 | 0.87 | ADRA1A (0.38) | PTGER3HSD11B1PER2CRY2TACR1 | |
| SCHEMBL13084710 | 0.83 | CHRM2 (0.39) | TACR1ADRA1AADRA1B | |
| SCHEMBL13036386 | 0.83 | CHRM2 (0.39) | TACR1ADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899320-B1 | SUBSTITUTED PYRR0LIDIN-2-0NES , PIPERIDIN-2-0NES AND ISOTHIAZOLIDINE-1, 1-DIOXIDES, THEIR USE AS KV1 .5 POTASSIUM CHANNEL BLOCKERS AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | SANOFI AVENTIS (FR) | 2010-10-20 | — | — | EP | disclosed |