Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.37 |
| ▸ | PER2 | O15055 | 2/20 | 0.33 |
| ▸ | CRY1 | Q16526 | 2/20 | 0.33 |
| ▸ | CRY2 | Q49AN0 | 2/20 | 0.33 |
| ▸ | CCR2 | P41597 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13086943 | 0.95 | MEN1 (0.39) | MEN1KMT2ACYP3A4MAPTALOX15 | |
| SCHEMBL13087154 | 0.88 | PIK3C3 (0.37) | PPARGPIK3C3CCR2KCNH2HRH3 | |
| SCHEMBL14706308 | 0.87 | PIK3C3 (0.34) | MEN1KMT2ACYP3A4MAPTALOX15 | |
| SCHEMBL13087222 | 0.85 | MCL1 (0.36) | PPARGPIK3C3CCR2KCNH2HRH3 | |
| SCHEMBL13087137 | 0.83 | PIK3C3 (0.42) | MEN1KMT2ACYP3A4MAPTALOX15 | |
| SCHEMBL13087186 | 0.81 | PIK3C3 (0.40) | MEN1KMT2ACYP3A4MAPTALOX15 | |
| SCHEMBL14706307 | 0.75 | PIK3C3 (0.42) | MEN1KMT2APIK3C3CCR2ALDH1A1 | |
| SCHEMBL13087065 | 0.74 | PIK3C3 (0.39) | PPARGPIK3C3CCR2 | |
| SCHEMBL13087049 | 0.73 | MKNK2 (0.41) | MEN1KMT2APIK3C3CCR2ALDH1A1 | |
| SCHEMBL13087203 | 0.72 | CCR2 (0.39) | PPARGPIK3C3CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8377928-B2 | 3-aminosulfonyl substituted indole derivatives and methods of use thereof | MERCK SHARP & DOHME CORP. (US) | 2013-02-19 | — | — | US | disclosed |
| US-8377928-B2 | 3-aminosulfonyl substituted indole derivatives and methods of use thereof | MERCK SHARP & DOHME CORP. (US) | 2013-02-19 | — | — | US | disclosed |
| US-20100260711-A1 | 3-AMINOSULFONYL SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100260711-A1 | 3-AMINOSULFONYL SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100260711-A1 | 3-AMINOSULFONYL SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF | IDO1, INMT, IDO2 | MEN1 2829/4885KMT2A 228/4885CYP3A4 1433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.