Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 15/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1306186 | 1.00 | ALDH1A1 (0.44) | ALDH1A1MAPK1HSD11B1HDAC1HDAC2 | |
| SCHEMBL12053708 | 1.00 | ALDH1A1 (0.44) | ALDH1A1MAPK1HSD11B1HDAC1HDAC2 | |
| SCHEMBL1307030 | 0.91 | HSD11B1 (0.39) | ALDH1A1MAPK1HSD11B1EPHX2 | |
| SCHEMBL1308015 | 0.90 | HSD11B1 (0.37) | HSD11B1EPHX2 | |
| SCHEMBL1306911 | 0.89 | IDH1 (0.43) | ALDH1A1MAPK1HSD11B1EPHX2 | |
| SCHEMBL1306917 | 0.89 | IDH1 (0.43) | ALDH1A1MAPK1HSD11B1EPHX2 | |
| SCHEMBL1307224 | 0.89 | IDH1 (0.43) | ALDH1A1MAPK1HSD11B1EPHX2 | |
| SCHEMBL1308433 | 0.88 | HSD11B1 (0.38) | ALDH1A1MAPK1HSD11B1EPHX2 | |
| SCHEMBL1308203 | 0.82 | TYRO3 (0.46) | HSD11B1EPHX2 | |
| SCHEMBL3809850 | 0.80 | HDAC1 (0.50) | ALDH1A1MAPK1HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053431-B2 | Pharmaceutical use of substituted amides | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-11-08 | — | — | US | claimed |
| US-8053431-B2 | Pharmaceutical use of substituted amides | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-11-08 | — | — | US | disclosed |