Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 3/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 6/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.37 |
| ▸ | CDK4 | P11802 | 4/20 | 0.37 |
| ▸ | CCND1 | P24385 | 4/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.37 |
| ▸ | CDK9 | P50750 | 4/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.37 |
| ▸ | CCR6 | P51684 | 4/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.36 |
| ▸ | CCND3 | P30281 | 2/20 | 0.36 |
| ▸ | CDK7 | P50613 | 2/20 | 0.36 |
| ▸ | CCNH | P51946 | 2/20 | 0.36 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13087584 | 0.92 | IKBKB (0.40) | DYRK1AIKBKBCDK2CCNA2CCND1 | |
| SCHEMBL13087754 | 0.91 | CDK2 (0.38) | DYRK1ACDK2CCNA2CCNT1CDK4 | |
| SCHEMBL13090060 | 0.89 | DYRK1A (0.43) | DYRK1AIKBKBIDO1CDK2CCNA2 | |
| SCHEMBL13087700 | 0.87 | DYRK1A (0.43) | DYRK1AIKBKBIDO1CDK2CCNT1 | |
| SCHEMBL13087368 | 0.87 | DYRK1A (0.47) | DYRK1AIKBKBIDO1CDK2CCNT1 | |
| SCHEMBL2429119 | 0.86 | IKBKB (0.45) | DYRK1AIKBKBIDO1CDK2CCNT1 | |
| SCHEMBL13087580 | 0.86 | DYRK1A (0.43) | DYRK1AIKBKBIDO1CDK2CCNT1 | |
| SCHEMBL13087640 | 0.86 | CCR6 (0.46) | DYRK1AIKBKBIDO1CDK2CCNA2 | |
| SCHEMBL2424533 | 0.86 | ROCK2 (0.43) | DYRK1AIDO1CDK2CCNA2CCNT1 | |
| SCHEMBL13087629 | 0.85 | DYRK1A (0.41) | DYRK1AIKBKBIDO1CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299055-B2 | 8-substituted isoquinoline derivative and the use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2012-10-30 | — | — | US | disclosed |
| US-8299055-B2 | 8-substituted isoquinoline derivative and the use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2012-10-30 | — | — | US | disclosed |
| US-20100261701-A1 | 8-Substituted isoquinoline derivative and the use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2010-10-14 | — | — | US | disclosed |
| US-20100261701-A1 | 8-Substituted isoquinoline derivative and the use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261701-A1 | 8-Substituted isoquinoline derivative and the use thereof | RELA, NFKBIA, NFKB2 | DYRK1A 2485/4885IKBKB 7/4885IDO1 514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.